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Articles by Sofia Appelberg
Dual-Antigen CCHFV Vaccine Induces Neutralizing Immunity and Protection Against Lethal Challenge
Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO-priority pathogen with high mortality and wide global distribution. A major challenge in CCHFV vaccine development is identifying antigens that induce functional cellular and humoral immunity. We previously showed that the CCHF nucleoprotein (NP) elicits protective responses in mice and non-human primates but does not induce neutralizing antibodies.
Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Ebola, Sudan, Marburg and Lassa viruse
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Flaxman A, Sebastian S, Appelberg S, Cha KM, Ulaszewska M, Purushotham J, et al. (2024) Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Ebola, Sudan, Marburg and Lassa viruse. PLoS Pathog 20(6): e1012262.
Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells - Nature Microbiology
Abstract Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in CCHFV infection in cell culture and blood vessel organoids.
P53-Independent G1-Cell Cycle Arrest Increases SARS-CoV-2 RNA Replication
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Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections - Nature Communications
Abstract Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In this study, using a haploid cell screening platform, we identify the guanine nucleotide exchange factor CCZ1 as a key host factor in the early stage of filovirus replication.
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