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What is already known about this subject SARS-CoV-2 infection and some vaccines against SARS-CoV-2 have been associated with an increased risk of venous thromboembolism (VTE). It is currently unknown if genetic variation is associated with thromboembolism following SARS-CoV-2 vaccination. This is the first genome-wide association study to investigate whether genetic variation could be associated with VTE after vaccination.
Key Points We developed a new method for the identification of potential risk factors for adverse drug reactions in a pharmacovigilance database. We used bleeding associated with direct oral anticoagulants (DOACs)-rivaroxaban, apixaban, edoxaban, and dabigatran-as a test model. We identified 13 risk factors of which 11 were previously known. Previously unknown potential risk factors were dementia and atrial fibrillation.
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