Skip To Main Content
Sofia Gaid on Muck Rack

Sofia Gaid

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile
Back to Sofia Gaid’s profile

Articles by Sofia Gaid

CReP-mediated control of eIF2α phosphorylation is a critical node in MYC-driven medulloblastoma

|
By Liliana Mirabal-Ortega, Magalie Larcher, Sara Chabi, Marion Le Grand, Kevin Muller, Jacob Torrejon, Moustapha Ka, Cristèle Gilbert, Véronique Marsaud, Bertrand DUVILLIE, Marine Blanchard, Boris Julien, Sophie Leboucher, Damarys Loew, Franck Bourdeaut, François Doz, Olivier Ayrault, Michael Taylor, Rachid Benhida, Eric Chevet, Eddy Pasquier, Sabine Druillennec, Celio Pouponnot, Sandra Majo, Lucie J Taunay, Laure Lagaye, Sofia Gaid, Coline Kerbaj, Franck Griscelli, Annelise Bennaceur-Griscelli, Florence M. Cavalli, Alain Eychène
| Nature Verified
Abstract Medulloblastoma (MB) is the most common malignant pediatric brain tumor. The MYC‑amplified group 3 (G3) MB represents a high‑risk disease lacking effective therapies. A genetic screen identified the endoplasmic reticulum chaperone HSPA5 (BiP/GRP78) as a critical dependency in G3 MB. Its silencing induces apoptosis and suppresses tumor growth, with strong activation of the unfolded protein response (UPR).
Open in Who Shared Issue with article?
Show More