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Abstract Structure predictions have become invaluable tools, but viral proteins are absent from the EMBL/DeepMind AlphaFold database. Here, we provide proteome-wide structure predictions for all nine human herpesviruses and analyze them in depth with explicit scoring thresholds. By clustering these predictions into structural similarity groups, we identified new families, such as the HCMV UL112-113 cluster, which is conserved in alpha- and betaherpesviruses.
Abstract Structure predictions have become invaluable tools for wet lab science by accelerating the generation of structure-based hypotheses. While AlphaFold-predicted structures are available for most proteins, viral proteins are currently absent from the EMBL/DeepMind AlphaFold database. Here, we provide proteome-wide structure predictions for all nine human herpesviruses and analyze them in depth. All predictions were scored using explicit thresholds.
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