Abstract Background: Genetic alterations play a crucial role in the pathogenesis and progression of papillary thyroid carcinoma (PTC). However, the diagnostic and prognostic significance of specific genetic alterations in PTC remains to be elucidated. This study aimed to evaluate the diagnostic performance of next-generation sequencing (NGS)-based genetic testing and to examine associations between genetic alteration subtypes and adverse clinicopathological features in PTC.
