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Abstract Treatment of metabolic acidosis with alkaline is established in clinical care of chronic kidney disease (CKD), although clinical studies revealed conflicting results whether it slows CKD. The aim of the study was to determine whether treatment strategies targeting serum bicarbonate concentrations of approximately 20 ± 1 or 24 ± 1 mmol/L differed with respect to eGFR decline over 104 weeks follow-up.
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