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Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
The SUPERB trial is an open-label, single-site, non-inferiority RCT with a 1:1 allocation ratio, comparing regional anaesthetic modality (UGSCB vs BB) for adult patients with upper limb fracture and/or dislocation requiring closed reduction and immobilisation in the ED. Eligible patients will be adults presenting to the ED with an upper limb fracture and/or dislocation requiring closed reduction, who have no contraindication to either UGSCB or BB.
References Kendall JM, Allen P, Younge P, Meek SM, McCabe SE. Haematoma block or Bier’s block for Colles’ fracture reduction in the accident and emergency department–which is best? J Accid Emerg Med. 1997;14(6):352–6. Article CAS PubMed PubMed Central Google Scholar Lowen R, Taylor J. Bier’s block - the experience of Australian emergency departments. Med J Aust. 1994;160(3):108–11. Article CAS PubMed Google Scholar duKamp A.
The main limitation from this systematic review and meta-analysis was the significant heterogeneity of studies. A random-effects model, using skewed weighting of individual data sets, was used to help compensate for this. Where heterogeneity was significant (I2 > 60%), meta-analysis was treated as hypothesis-generating only for main outcome measures and not performed for subgroups.
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