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Stefan Cap

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Articles by Stefan Cap

Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses

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By Nikola Cousin, Stefan Cap, Manuel Dihr
| cancerres.aacrjournals.org
Tumor Biology and Immunology Nikola Cousin, Stefan Cap, Manuel Dihr, Carlotta Tacconi, Michael Detmar and Lothar C. Dieterich DOI: 10.1158/0008-5472.CAN-21-0633 Published August 2021 Abstract Lymph node (LN)–resident lymphatic endothelial cells (LEC) mediate peripheral tolerance by self-antigen presentation on MHC-I and constitutive expression of T-cell inhibitory molecules, including PD-L1 (CD274).
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Lymphatic PD-L1 expression restricts tumor-specific CD8+ T cell responses

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By Carlotta Tacconi, Nikola Cousin, Stefan Cap, Manuel Dihr
| cancerres.aacrjournals.org
Research Article Nikola Cousin, Stefan Cap, Manuel Dihr, Carlotta Tacconi, Michael Detmar and Lothar C. Dieterich DOI: 10.1158/0008-5472.CAN-21-0633 Abstract Lymph node (LN)-resident lymphatic endothelial cells (LEC) mediate peripheral tolerance by self-antigen presentation on MHC-I and constitutive expression of T cell inhibitory molecules, including PD-L1. Tumor-associated LECs also upregulate PD-L1, but the specific role of lymphatic PD-L1 in tumor immunity is not well understood.
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