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Articles by Stéphane Isnard
Cell death–induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation
Abstract Acyl-CoA–binding protein (ACBP, encoded by diazepam binding inhibitor, DBI) is an abundant intracellular regulator of lipid metabolism that also circulates systemically, yet the mechanisms governing its release and its relationship to organ injury remain unresolved. Herein, we combine human multi-omics, mechanistic mouse models and controlled cell death assays to identify cell death–driven liberation of intracellular ACBP/DBI as a unifying mechanism underlying its elevation in disease.
JoF | Free Full-Text | The Influence of Oral Terbinafine on Gut Fungal Microbiome Composition and Microbial Translocation in People Living with HIV Treated for Onychomycosis
1. Introduction In the era of antiretroviral therapy (ART), increased microbial translocation and chronic immune activation have been identified as two critical health issues for people living with HIV (PLWH) [1]. Convergent evidence indicates that PLWH display an altered composition of their intestinal microbiota and their by-products, a concept referred to as dysbiosis [2,3].
Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1
Abstract : Like other chronic viral infections, HIV-1 persistence inhibits the development of antigen-specific memory T-cells, resulting in the exhaustion of the immune response and chronic inflammation. Autophagy is a major lysosome-dependent mechanism of intracellular large-target degradation such as lipid and protein aggregates, damaged organelles, and intracellular pathogens.
Memory SARS-CoV-2 T-cell response in convalescent COVID-19 patients with undetectable specific IgG antibodies: a comparative study
Raquel Fernández-Moreno1,2, Jorge Valle-Arroyo2, Aurora Páez-Vega1,2, Ana Salinas2, Angela Cano1,2,3, Ana B.
Influence of letermovir treatment on gut inflammation in people living with HIV on antiretroviral therapy: protocol of the open-label controlled randomised CIAO study
Methods and analysis Study design, settings, sample size and recruitment strategy Trial CTN PT047, referred as the CIAO (‘CMV Inhibition with letermovir in ART-treated people living with HIV: an Open-label, randomized, controlled trial’) study is a multi-centre, open-label, randomised, controlled clinical trial to assess the influence of letermovir on gut translocation (LPS and BDG markers) in blood in ART-treated CMV-seropositive adult PLWH; protocol version # 2.1; 27 July 2022.
Camu Camu effects on microbial translocation and systemic immune activation in ART-treated people living with HIV: protocol of the single-arm non-randomised Camu Camu prebiotic pilot study (CIHR/CTN PT032)
Methods and analysis Study design, settings, sample size and recruitment strategy Trial CTN PT032 is an open label, non-randomised, single arm interventional pilot study (Clinicaltrials.gov NCT04058392); protocol version # 1.3; February 12, 2021. The study sponsor is the Canadian Institutes of Health Research Canadian HIV Trials Network (CTN).
Cell-Associated HIV Cross-Presentation by Plasmacytoid Dendritic Cells Is Potentiated by Noncognate CD8+ T Cell Preactivation
Stéphane Isnard, Etienne X. Hatton, Marco Iannetta, Jean-Baptiste Guillerme and Anne Hosmalin J Immunol July 1, 2021, 207 (1) 15-22; DOI: https://doi.org/10.4049/jimmunol.2000392 Key Points HIV-infected H9 cells induce type I IFN production by pDC. Type I IFN induces IFN-γ but not granzyme B intracellular production in CD8+ T cells. Type I IFN potentiates IFN-γ secretion only upon cognate cross-presentation by pDC.
Cell-Associated HIV Cross-Presentation by Plasmacytoid Dendritic Cells Is Potentiated by Noncognate CD8+ T Cell Preactivation
Stéphane Isnard, Etienne X. Hatton, Marco Iannetta, Jean-Baptiste Guillerme and Anne Hosmalin J Immunol June 25, 2021, ji2000392; DOI: https://doi.org/10.4049/jimmunol.2000392 Key Points HIV-infected H9 cells induce type I IFN production by pDC. Type I IFN induces IFN-γ but not granzyme B intracellular production in CD8+ T cells. Type I IFN potentiates IFN-γ secretion only upon cognate cross-presentation by pDC.
Abstract PR04: Potential of metformin to modify the gut microbiota and prevent inflammation in nondiabetic people with HIV
Oral Presentations - Proffered Abstracts Stéphane Isnard, John Lin, Brandon Frombuena, Thibaut V.
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