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Abstract Interleukin-33 (IL-33) is a central regulator of immune responses and inflammation, and genetic variation in IL33 and its receptor IL1RL1 (ST2) is strongly linked to disease susceptibility, notably asthma. Emerging evidence suggests that IL-33 also influences hematopoietic processes and platelet biology, indicating functions beyond canonical immunity.
(a) Oxidative stress plays a critical role in IL-33 release following exposure of human primary cells to A. alternata. Intact monolayers of IL-33-producing endothelial cells were exposed to different stimuli in the presence or absence of antioxidant glutathione (GSH, 10 mM) and release of endogenous IL-33 in cell supernatants was analyzed by ELISA. Stimuli included A.
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