Key Points Question Do age-stratified trends in colorectal cancer (CRC) mortality rates vary across county, race and ethnicity, and sex in the US? Findings In this cross-sectional study including a mean annual population of all 306 million US adults, substantial variation was observed in county-level CRC mortality rates in adults aged 45 years or older across racial and ethnic and sex populations, with CRC mortality rates exceeding 100 deaths per 100 000 population in some counties.
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