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Articles by Stephen Spatz
A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Volkening JD, Spatz SJ, Garcia M, Ross TA, Maekawa DA, Rosenthal KS, et al. (2025) A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor. PLoS Pathog 21(7): e1013219.
A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: unveiling a novel virulence factor
Abstract Herpesviruses have evolved numerous immune evasion tactics, persisting within their hosts through self-perpetuating strategies. One such tactic involves acquiring functional copies of host genes encoding cytokines such as IL-6 (HHV-8), IL-8 (GaHV-2), IL-10 (HHV-4, HHV-5), and IL-17 (SaHV-2). These viral mimics, or virokines, can bind to cellular receptors, modulating the natural cytokine signaling and manipulating the immune response to favor the virus.
Non-Targeted RNA Sequencing: Towards the Development of Universal Clinical Diagnosis Methods for Human and Veterinary Infectious Diseases
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Viral proteogenomic and expression profiling during productive replication of a skin-tropic herpesvirus in the natural host
IsoSeq data analysis Data preprocessing and transcript calling. Raw PacBio subreads were processed to circular consensus sequencing (CCS) reads using ccs v6.4.0 (‐‐min-rq 0.9) (this and all other PacBio software referenced was installed from the PacBio Bioconda packages https://github.com/PacificBiosciences/pbbioconda) [84]. Demultiplexing and adapter removal was performed using lima v2.7.1 (‐‐isoseq–peekguess).
The Tegument Protein pUL47 of Marek’s Disease Virus Is Necessary for Horizontal Transmission and Is Important for Expression of Glycoprotein gC
Pathogenesis and Immunity Aurélien Chuard, Katia Courvoisier-Guyader, Sylvie Rémy, Stephen Spatz, Caroline Denesvre, David Pasdeloup Felicia Goodrum, Editor DOI: 10.1128/JVI.01645-20 ABSTRACT Viral tropism and transmission of herpesviruses are best studied in their natural host for maximal biological relevance. In the case of alphaherpesviruses, few reports have focused on those aspects, primarily because of the few animal models available as natural hosts that are compatible with such studies.
The tegument protein pUL47 of Marek's Disease Virus is necessary for horizontal transmission and is important for expression of glycoprotein gC
Pathogenesis and Immunity Aurélien Chuard, Katia Courvoisier-Guyader, Sylvie Rémy, Stephen Spatz, Caroline Denesvre, David Pasdeloup DOI: 10.1128/JVI.01645-20 ABSTRACT Viral tropism and transmission of Herpesviruses are best studied in their natural host for maximal biological relevance. In the case of α-herpesviruses, few reports have focused on those aspects, primarily because of the few animal models available as natural hosts that are compatible with such studies.
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