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Articles by Steven A Curley
I've been a surgeon for 25 years. Death never gets easier.
The family of the patient whose operation I had just completed was sitting expectantly in the consultation room in the surgical waiting area. I was out way too soon. I had started the operation less than an hour before. The patient I operated on had a bile duct cancer called hilar cholangiocarcinoma. The patient was diagnosed with this tumor when his eyes and skin rapidly became bright yellow.
Cancer Care in the Future
The future of cancer care should mean more cost-effective treatments, a greater focus on prevention, and a new mindset: A Surgical Oncologist’s take Multidisciplinary team management of many types of cancer has led to significant improvements in median and overall survival. Unfortunately, there are still other cancers which we have impacted little.
Autophagy and enhanced chemosensitivity in experimental pancreatic cancers induced by noninvasive radiofrequency field treatment.
Among the solid tumors, human pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis. Gemcitabine is the standard first line of therapy for pancreatic cancer but has limited efficacy due to inherent or rapid development of resistance and combining EGFR inhibitors with this regimen results in only a modest clinical benefit. The goal of this study was to identify molecular targets that are activated during gemcitabine therapy alone or in combination with an EGFR inhibitor.
Noninvasive radiofrequency treatment effect on mitochondria in pancreatic cancer cells.
Patients with pancreatic ductal adenocarcinoma (PDAC) have limited therapeutic options and poor response to the standard gemcitabine (GCB)-based chemotherapy. In the current study, the authors investigated the feasibility of noninvasive short-wave radiofrequency (RF) electric fields to improve the cytotoxic effect of GCB on PDAC cells and determined its mechanism of action.
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