4. Discussion The LRR rate for solid tumors remains as high as 65%, even in the absence of distant disease [4]. Historically, stage IV solid tumors are typically not resected due to the high risk of palliative surgery [35]. We demonstrated that CHCP treatment in combination with surgery is a viable option for controlling LRR and possibly improving overall survival. CHCP is a safe and potentially effective treatment option for a wide range of Stage IV or Recurrent solid tumors.