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There were more than 47,000 fatal drug overdoses in the United States during 2014, with roughly two thirds of those deaths linked to opioids.[1] Synthetic opioids, such as fentanyl, are involved in the mortality rates. Nonpharmaceutical fentanyls (NPFs) are potent opioid receptor agonists that cause a toxidrome characterized by profound central nervous system and respiratory depression.
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