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Discussion We have shown that the prevalence of 17q12 recurrent microduplications is 1 in 4607 (n=106) and 1 in 44 398 for microdeletions (n=11) in a population-based cohort of 488 377 individuals in the UKB.
Methods The UK Biobank recruited a sample of more than 500 000 individuals between the ages of 37 and 73 years from 2006 to 2010 across the UK.14 At baseline, participants completed detailed questionnaires on health, sociodemographic and lifestyle factors. Blood and urine samples were obtained for genetic analysis along with a broad range of markers of health and disease.
Loading metrics Open Access Peer-reviewed Research Article Abstract Global banana production is currently challenged by Panama disease, caused by Fusarium oxysporum f.sp. cubense Tropical Race 4 (FocTR4). There are no effective fungicide-based strategies to control this soil-borne pathogen. This could be due to insensitivity of the pathogen to fungicides and/or soil application per se.
Abstract Transitioning from spores to hyphae is pivotal to host invasion by the plant pathogenic fungus Zymoseptoria tritici. This dimorphic switch can be initiated by high temperature in vitro (~27 °C); however, such a condition may induce cellular heat stress, questioning its relevance to field infections. Here, we study the regulation of the dimorphic switch by temperature and other factors.
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