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Articles by Sujun Li
Non-gene-edited, CD19-targeted, allogeneic CAR-T cell therapy for relapsed or refractory B-cell acute lymphoblastic leukemia: an open-label, single-arm phase 1 study
Abstract Autologous chimeric antigen receptor (CAR)-T cell therapy is effective in relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL), but its clinical application is restricted by manufacturing failures, high costs, and limited accessibility. Gene-edited allogeneic CAR-T cells offer an off-the-shelf alternative, yet concerns remain regarding genomic instability and graft-versus-host disease (GVHD).
CLN7 suppression induces apoptosis via mTOR-regulated and chaperone-mediated autophagy in myeloid leukemia cells
Abstract Refractory disease and relapse continue to impede effective treatment of myeloid leukemia, despite substantial progress in therapeutic approaches. Emerging evidence implicates lysosomal ion channels in the regulation of cell death pathways, highlighting these channels as viable targets for therapeutic intervention. This study identified elevated expression of the lysosomal ion channel CLN7 in myeloid leukemia cells.
FIDDLE: a deep learning method for chemical formulas prediction from tandem mass spectra
5 hours ago When did you stop being creative and start being operational? When was the moment you shifted from building to maintaining? You know it happened. But when you don’t have time for big ideas. When you’re too busy to let your mind wander. That's the inflection point where businesses die. Little do you …
FIDDLE: a deep learning method for chemical formulas prediction from tandem mass spectra
Abstract Molecular identification through tandem mass spectrometry is fundamental in metabolomics, with formula identification serving as the initial step in the process. However, current computation-based methods for formula identification face challenges, such as limited accuracy and extensive running times, with some methods unable to predict formulas for relatively large molecules. The limitations may impede high-throughput workflows and diminish overall research efficiency and success.
3DMolMS: Prediction of Tandem Mass Spectra from Three Dimensional Molecular Conformations
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Keeping an Eye on Gene Therapy
Review Article | 23 Oct 2019 | Eye Article | Open Access | 2 Mar 2020 | Gene Therapy Article | 27 Aug 2019 | Eye Article | Open Access | 14 Oct 2019 | Gene Therapy Comment | Open Access | 9 Mar 2020 | Eye Article | 17 Jul 2019 | Eye Review Article | Open Access | 5 Mar 2018 | Eye Review Article | 10 Nov 2017 | Eye Clinical Study | Open Access | 18 Aug 2017 | Eye Article | Open Access | 26 Sep 2018 | Gene Therapy Cambridge Ophthalmological Symposium | 13 Jan 2017 | Eye Laboratory Study | 17...
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