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Aim: This study investigated the safety and clinical outcomes of expanded allogeneic human adipose-derived mesenchymal progenitor cells injected into patients with symptomatic, bilateral knee osteoarthritis. Design: In this single-site, randomized, double-blind, dose-ranging, Phase I study, patients were randomized to three treatment groups (low dose, 1 × 107 cells; medium dose, 2 × 107 cells; high dose, 5 × 107 cells).
C Dai, L Zhang and S Li are employees of Cellular Biomedicine Group Ltd. The research funding and adipose-derived mesenchymal stem cells were provided by Cellular Biomedicine Group Ltd. The pending patent (CN201210466717.6) belongs to Cellular Biomedicine Group Ltd.
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