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Signals of nerve impulses are transmitted to excitatory cells to induce the action of organs via the activation of Ca2+ entry through voltage-gated Ca2+ channels (VGCC), which are classified based on their activation threshold into high- and low-voltage activated channels, expressed specifically for each organ. Ca2+ entering into excitatory cells binds to Ca2+-binding proteins, which are classified into two groups of Ca2+ sensors: C2 domain and EF hand proteins.
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