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To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Bias often confounds interpretation of research trial results. Best Endovascular versus Best Surgical Therapy for Patients with Critical Limb Ischemia (BEST-CLI) is a randomized trial comparing surgical and endovascular revascularization strategy in patients with CLI.
Background Critical limb ischemia (CLI) is increasing in prevalence, and remains a significant source of mortality and limb loss. The decision to recommend surgical or endovascular revascularization for patients who are candidates for both varies significantly among providers and is driven more by individual preference than scientific evidence.
Importance Thrombocytopenia and intraventricular hemorrhage (IVH) are common among very-low-birth-weight (VLBW) infants. Survey results suggest that US neonatologists frequently administer platelet transfusions to VLBW infants with mild to moderate thrombocytopenia.
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