DAT dopamine transporter ICP intracavernosal pressure l-NOARG NG-nitro-l-arginine MAP mean arterial pressure NAT noradrenaline transporter PDE5 phosphodiesterase type 5 SERT serotonin transporter What is already known An estimated 40% of patients with erectile dysfunction have no improvement with currently available treatments. What does this study add The monoamine reuptake inhibitor, IP2015, stimulates erection via a central dopaminergic mechanism and NO-mediated peripheral relaxation.