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Articles by Suzie Pun
Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations
Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations Aptamers are single-stranded nucleic acids that bind and recognize targets much like antibodies. Recently, aptamers have garnered increased interest due to their unique properties, including inexpensive production, simple chemical modification, and long-term stability. At the same time, aptamers possess similar binding affinity and specificity as their protein counterpart.
Synthesis and characterization of anionic poly(cyclopentadienylene vinylene) and its use in conductive hydrogels
Research Article Suzie Pun Corresponding Author E-mail address: spun@u.washington.edu University of Washington, Bioengineering, 3720 15th Ave NE, Box 355061, 98195 Seattle, UNITED STATES Search for more papers by this author Abstract The use of π‐conjugated polymers (CPs) in conductive hydrogels remains challenging due to the water‐insoluble nature of most CPs. Conjugated polyelectrolytes (CPEs) are promising alternatives because they have tunable electronic properties and high...
Traceless aptamer-mediated isolation of CD8+ T cells for chimeric antigen receptor T-cell therapy
Abstract Chimeric antigen receptor T-cell therapies using defined product compositions require high-purity T-cell isolation systems that, unlike immunomagnetic positive enrichment, are inexpensive and leave no trace on the final cell product. Here, we show that DNA aptamers (generated with a modified cell−SELEX procedure to display low-nanomolar affinity for the T-cell marker CD8) enable the traceless isolation of pure CD8+ T cells at low cost and high yield.
Identifying key barriers in cationic polymer gene delivery to human T cells
Identifying key barriers in cationic polymer gene delivery to human T cells Brynn R. Olden,a Emmeline Cheng,a Yilong Chenga and Suzie H. Pun*a Abstract T cells have emerged as a therapeutically-relevant target for ex vivo gene delivery and editing. However, most commercially available reagents cannot transfect T cells and designing cationic polymers for non-viral gene delivery to T cells has resulted in moderate success.
Identifying key barriers in cationic polymer gene delivery to human T cells
Identifying key barriers in cationic polymer gene delivery to human T cells Brynn Olden, Emmeline Cheng, Yilong Cheng and Suzie Pun Abstract T cells have emerged as a therapeutically-relevant target for ex vivo gene delivery and editing. However, most commercially available reagents cannot transfect T cells and designing cationic polymers for non-viral gene delivery to T cells has resulted in moderate success.
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