Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Sven Epple
Correction: Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)
Correction: Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2) Correction for ‘Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)’ by Alice Kennett et al., Chem. Commun., 2024, 60, 436–439, https://doi.org/10.1039/D3CC02565A. This article is Open Access This article has not yet been cited.
Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)
Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)† Sulf-2 has been identified as a putative target for anticancer therapies. Here we report the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S). Trisulfated disaccharide inhibitor IdoA(2S)-GlcNS(6Sulfamate) demonstrated potent Sulf-2 inhibition.
Modified minimal-size fragments of Heparan Sulfate as inhibitors of endosulfatase-2 (Sulf-2)
Modified minimal-size fragments of Heparan Sulfate as inhibitors of endosulfatase-2 (Sulf-2) Endosulfatase-2 (Sulf-2) has been identified as a putative target for anticancer therapeutics, however, the biological characterisation of this enzyme has been limited by the lack of potent, selective and easily synthesised inhibitors.
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides - Nature Communications
Abstract Oligonucleotides that target mRNA have great promise as therapeutic agents for life-threatening conditions but suffer from poor bioavailability, hence high cost. As currently untreatable diseases come within the reach of oligonucleotide therapies, new analogues are urgently needed to address this. With this in mind we describe reduced-charge oligonucleotides containing artificial LNA-amide linkages with improved gymnotic cell uptake, RNA affinity, stability and potency.
A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility
Introduction The replacement of natural phosphodiester (PO) bonds in DNA or RNA by artificial internucleoside linkages can generate remarkable biomimetic oligonucleotides (ONs) with applications as therapeutics,(1) xenobiotic genetic polymers,(2−4) aptamers,(3,5−7) and synthetic genes.(8−10) Biological integrity and favorable biophysical properties are critical, and good hybridization properties, mismatch discrimination, and compatibility with certain enzymes (e.g., RNase H) play crucial...
Consecutive 5′- and 3′-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response
This article is Open Access Please wait while we load your content... Something went wrong. Try again?
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Sven
Contact Sven, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack