Objective To determine whether family informational and emotional support meetings led by palliative care clinicians improve family anxiety and depression. Design, Setting, and Participants A multicenter randomized clinical trial conducted from October 2010 through November 2014 in 4 medical intensive care units (ICUs). Adult patients (aged ≥21 years) requiring 7 days of mechanical ventilation were randomized and their family surrogate decision makers were enrolled in the study.