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BACKGROUND The STAR AF II (Substrate and Trigger Ablation for Reduction of Atrial Fibrillation 2) was a multicenter, randomized trial which randomized patients to pulmonary vein isolation (PVI) alone, PVI plus complex fractionated electrograms (CFE), or PVI plus linear ablation (roof line and mitral line). The study failed to show any additional benefit of additional substrate ablation (CFE or lines) in addition to PVI.
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