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Abstract Mycophenolate mofetil (MMF) is commonly prescribed and has proven advantages over other immunosuppressive drugs. However, frequent gastrointestinal side effects through an unknown mechanism limit its use. We have found that consumption of MMF alters the composition of the gut microbiota, selecting for bacteria expressing the enzyme β-glucuronidase (GUS) and leading to an up-regulation of GUS activity in the gut of mice and symptomatic humans.
In this study we have shown that EHR data in combination with historical patterns of flu activity and a robust dynamical machine learning algorithm, are capable of accurately predicting real-time influenza activity at the national and regional scales in the US.
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