Original Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/febs.16894. Abstract: FKBP25 (FKBP3 gene), is a dual domain PPIase protein that consists of a C-terminal PPIase domain, and an N-terminal basic tilted helix bundle (BTHB).