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ABBV-1 aquatic bird bornavirus 1 ABV avian bornavirus BoDV-1 Borna disease virus 1 ORF open reading frame P phosphoprotein PaBV-4 parrot bornavirus 4 PaBV-5 parrot bornavirus 5 uORF upstream open reading frame UTR untranslated region vRNP viral ribonucleoprotein complex WT wild type X accessory protein 1 Introduction Orthobornaviruses are nonsegmented, negative-sense, single-stranded RNA viruses in the genus Orthobornavirus within the family Bornaviridae [1, 2].
Abstract Borna disease virus 1 (BoDV-1) causes acute fatal encephalitis in mammals, including humans. Despite its importance, research on BoDV-1 cell entry has been hindered by low viral particle production in cells and the lack of cytopathic effects. To address these issues, we developed a method to efficiently produce vesicular stomatitis virus (VSV) pseudotyped with glycoprotein (G) of the genus Orthobornavirus, including BoDV-1.
Abstract Viruses belonging to the genus Orthobornavirus within the family Bornaviridae are known to infect various vertebrate species, including mammals and birds. Within the genus, the species Orthobornavirus bornaense includes two mammalian viruses: Borna disease virus 1 (BoDV-1), the prototype of the family, and its closely related virus, BoDV-2. BoDV-1 was identified as the causative agent of Borna disease (BD) in horses, sheep, humans, and other mammals.
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