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Takuya Kubota

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Articles by Takuya Kubota

TFEB drives ER stress-induced apoptosis and limits cyst growth in polycystic kidney disease

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By Jun Nakamura, Sho Matsui, Takeshi Yamamoto, Hideaki Kawai, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Isao Matsui, Gaku Yamamichi, Taigo Kato, Norio Nonomura, Saori Nishio, Tamotsu Yoshimori, Yoshitaka Isaka, Takuya Kubota, Shun Takenaka
| Nature Verified
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive growth of renal cysts and loss of renal function. Here, it was demonstrated that transcription factor EB (TFEB) activation in cyst-lining epithelial cells enhances their susceptibility to apoptosis via endoplasmic reticulum (ER) stress-induced signaling, ultimately restricting cyst expansion.
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