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Abstract The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neurogenesis remain elusive. Here, we comprehensively mapped 3D genome organization, chromatin accessibility and gene expression in induced pluripotent stem cells and derived neural stem cells from human, chimpanzee, gorilla and macaque.
ATP Adenosine triphosphate BMR Basal metabolic rate DNA Deoxyribonucleic acid FDR False discovery rate HRV Heart rate variability OLS Ordinary least squares PCA Principal Component Analysis PGLS Phylogenetic generalised least squares RHR Resting heart rate RNA Ribonucleic acid ROS Reactive Oxygen Species 1 INTRODUCTION Understanding processes that drive ageing and determine the longevity of organisms, has been a subject of intensive research in the past 100 years (Table 1) (Robin Harris &...
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
