Introduction Cancer screening can be effective at early-stage detection, but, currently, only around 6% of cancers in the UK are screen-detected with programmes for cervical, colorectal, breast, and more recently targeted lung cancer screening.1 Increasing areas of interest are cancer detection tests based on circulating tumour-derived DNA (ctDNA) and their potential role in cancer screening,2 with multiple blood-based tests being developed.3 These are designed to detect potential cancer...