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Key Points Question Is physical frailty independently associated with a higher risk of incident Parkinson disease (PD)? Findings In this cohort study of 314 998 participants with over 12 years of follow-up, the study team observed that prefrailty and frailty were associated with a 26% and 87% increased risk of PD, respectively. The genetic risk of PD modified the association between frailty and PD.
Plasma Alkylresorcinol Metabolite, a Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Type 2 Diabetes and Impaired Glucose Regulation in a Chinese Population Taoping Sun, Ying Rong, Xiaoli Hu, Yalun Zhu, Hao Huang, Liangkai Chen, Peiyun Li, Shuzhen Li, Wei Yang, Jinquan Cheng, Xuefeng Yang, Ping Yao, Frank B. Hu, Liegang Liu Diabetes Care Mar 2018, 41 (3) 440-445; DOI: 10.2337/dc17-1570
This study was funded by the National Science and Technology Support Program of China (2012BAI02B02), the China Postdoctoral Science Foundation (2016M602314), the Sanming Project of Medicine in Shenzhen, and the Fundamental Research Funds for the Central Universities (HUST 2016YXMS219). Background: The association of trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite from dietary choline and carnitine, with type 2 diabetes was inconsistent.
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