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Articles by Thomas Chartrand
Defining sustainable chemistry-an opportune exercise?
I lost my elephant some days ago. Actually, it was an elephant keychain. This was a special present given by a Thai student who attended the Summer School on Sustainable Chemistry for Sustainable Development in July 2023, at Leuphana University, Germany, supported by the International Sustainable Chemistry Collaborative Centre (ISC3).
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 6 October 2022 Accepted: 9 September 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments We thank the Allen Institute founder, Paul G. Allen, for his vision, encouragement, and support. This publication was supported by and coordinated through the Brain Initiative Cell Census Network (BICCN).
Comparative transcriptomics reveals human-specific cortical features
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 19 September 2022 Accepted: 13 September 2023 Published in print: 13 October 2023 Permissions Request permissions for this article.
Transcriptomic diversity of cell types across the adult human brain
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 29 September 2022 Accepted: 7 September 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments We thank the Linnarsson group for feedback and discussion, especially A. Johnsson for laboratory management, E. Kvedaraite for immune cell annotation, E. Vinsland for fibroblast and vasculature annotation, and I. Kapustová for artwork.
Early Homo erectus lived at high altitudes and produced both Oldowan and Acheulean tools
Acknowledgments We are grateful to the Authority for Research and Conservation of the Cultural Heritage and to the Ministry of Culture and Tourism of the Federal Republic of Ethiopia for the loan and temporary export permit of MK 81 GAR IVE 0043 (November 27, 2015-January 26, 2016) awarded to M. Mussi.
Erratum for the Research Article “The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2” by J. E. Pekar et al.
In the Research Article “The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2,” the frequency of simulated topologies matching phylogenetic structures arising from a single introduction was incorrectly reported because of an error in the code, which has been corrected. Correspondingly, the Bayes factors in favor of multiple introductions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the human population relative to a single introduction were overestimated.
Probiotic-guided CAR-T cells for solid tumor targeting
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 16 August 2022 Accepted: 24 August 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments We thank M. Sadelain for providing the ffLuc+ Nalm6 acute lymphoblastic leukemia cell line, R. Schwabe for providing the Huh7 hepatoma cell line, and S. Acharyya for providing the PYMT-derived cell line. We thank N.
Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly
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Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 2 December 2022 Accepted: 16 August 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments We thank the FMP mass spectrometry core facility, especially H. Stephanowitz for proteomic analysis, W.-T. Lo (FMP, Berlin) for assistance with protein purification and liposome binding assays, and B. Van Rossum for help with the artwork.
By Kimberly Siletti, Nikolas L. Jorstad, Thomas Chartrand, Filiz Sila Rizalar, Astrid G. Petzoldt, Shuhan Kong, Jiachen Sun, james vines, Sebastian Diecke, Thomas Kaas, Christopher Schmied, Jason King, Stefan Hallermann, Wonhwa Cho, Max T. Lucht, Narasimha Swamy Telugu, Torsten Bullmann, Delia Löwe, Dmytro Puc
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Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 1 July 2023 Accepted: 23 August 2023 Published in print: 13 October 2023 Permissions Request permissions for this article.
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 5 June 2023 Accepted: 28 August 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments We thank B. T. Boyle, N. W. Dow, O. L. Garry, C. A. Gould, B. X. Li, Y. Liang, W. Liu, C. N. Prieto-Küllmer, and C. P. Seath for helpful scientific discussions; D. G. Oblinsky and M. D. Woodhouse for preliminary spectroscopy; K. Conover and I. Pelczer for NMR support; J.
Boom-bust cycles in gray whales associated with dynamic and changing Arctic conditions
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 8 April 2023 Accepted: 16 August 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments We thank past and present members of the Working Group for Marine Mammal Unusual Mortality Events; the Gray Whale Unusual Mortality Event Investigative Teams; as well as the US, Canadian, and Mexico marine mammal stranding network responders.
In Science Journals
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Research Highlights Metallurgy Stacking fault mosaic Brent Grocholski Metal alloys often get harder as you strain them because of the creation and entanglement of line defects. Pan et al. found a different mechanism for this strain hardening in a multi–principal element alloy at liquid nitrogen temperature. The alloy forms a mosaic of small stacking faults oriented in different directions instead of linear defects.
By Kimberly Siletti, Nikolas L. Jorstad, Thomas Chartrand, Brent Grocholski Verified, Michael Funk Verified, Mattia Maroso, Jake Yeston Verified, Sarah Ross, Marc S. Lavine Verified, Dorothy Hallberg, Sacha Vignieri Verified, Gemma Alderton, Priscilla Kelly Verified, John Foley
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Protect central Chile’s biodiversity
Information & Authors Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Published in print: 13 October 2023 Permissions Request permissions for this article. Competing Interests J.F.P.-Q. and R.S. signed the #QueremosParque petition as citizens but are not affiliated with the campaign.
Single-cell analysis of prenatal and postnatal human cortical development
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 24 October 2022 Accepted: 31 August 2023 Published in print: 13 October 2023 Permissions Request permissions for this article.
Photocatalysis gets energized by abundant metals
Perspective Chemistry Cobalt compounds might enable cheaper and more-complex photocatalysis processes Get full access to this article View all available purchase options and get full access to this article. References and Notes 1 A. Y. Chan et al., Science 382, 191 (2023). 2 M. D. Woodhouse, J. K. McCusker, J. Am. Chem. Soc. 142, 16229 (2020). 3 L. H. M. de Groot et al., J. Am. Chem. Soc. 145, 9369 (2023). 4 S. Kaufhold et al., J. Am. Chem. Soc. 143, 1307 (2021). 5 J. T. Yarranton, J. K. McCusker, J. Am. Chem. Soc.
Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon
Special Issue Research Article BICCN Get full access to this article View all available purchase options and get full access to this article. Supplementary Materials Supplementary Text Figs. S1 to S19 References (92–98) MDAR Reproducibility Checklist References and Notes 1 A. R. Ypsilanti, K. Pattabiraman, R. Catta-Preta, O. Golonzhka, S. Lindtner, K. Tang, I. R. Jones, A. Abnousi, I. Juric, M. Hu, Y. Shen, D. E. Dickel, A. Visel, L. A. Pennachio, M. Hawrylycz, C. L. Thompson, H. Zeng, I. Barozzi, A. S. Nord, J. L.
Comprehensive cell atlas of the first-trimester developing human brain
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 30 September 2022 Accepted: 9 August 2023 Published in print: 13 October 2023 Permissions Request permissions for this article.
Chiral molecules to transmit electron spin
Understanding how electrons move through molecules and carry energy with them has been crucial for the development of multiple technologies, including photovoltaic cells and light-emitting diodes. The standard theory () establishes that electron transfer (ET) can be understood by considering energy conservation and the movement of electrons and nuclei.
Single-cell DNA methylation and 3D genome architecture in the human brain
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 7 November 2022 Accepted: 5 September 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments This publication was supported by and coordinated through the NIH’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative - Cell Census Network (BICCN).
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 6 October 2022 Accepted: 9 September 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments We thank the Allen Institute founder, Paul G. Allen, for his vision, encouragement, and support. This publication was supported by and coordinated through the Brain Initiative Cell Census Network (BICCN).
Transcriptomic cytoarchitecture reveals principles of human neocortex organization
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 6 November 2022 Accepted: 8 September 2023 Published in print: 13 October 2023 Permissions Request permissions for this article.
Transcriptomic diversity of cell types across the adult human brain
Materials and methods Deidentified postmortem adult human brain tissue was obtained after receiving permission from the deceased’s next-of-kin. Tissue collection was performed in accordance with the provisions of the United States Uniform Anatomical Gift Act of 2006 described in the California Health and Safety Code section 7150 (effective 1/1/2008) and other applicable state and federal laws and regulations.
Spatiotemporal molecular dynamics of the developing human thalamus
Supplementary Materials MDAR Reproducibility Checklist References and Notes 1 R. W. Guillery, Anatomical evidence concerning the role of the thalamus in corticocortical communication: A brief review. J. Anat.187, 583–592 (1995). 2 M. K. L. Baldwin, P. Balaram, J. H. Kaas, The evolution and functions of nuclei of the visual pulvinar in primates. J. Comp. Neurol.525, 3207–3226 (2017). 3 J. Homman-Ludiye, J. A. Bourne, The medial pulvinar: Function, origin and association with neurodevelopmental disorders. J.
A comparative atlas of single-cell chromatin accessibility in the human brain
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 9 November 2022 Accepted: 14 September 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments This publication was supported by and coordinated through BICCN. This publication is part of the Human Cell Atlas (www.humancellatlas.org/publications). We thank E. Melief, A. Schantz, K. Kern, A. Keen, and L.
Defining sustainable chemistry-an opportune exercise?
I lost my elephant some days ago. Actually, it was an elephant keychain. This was a special present given by a Thai student who attended the Summer School on Sustainable Chemistry for Sustainable Development in July 2023, at Leuphana University, Germany, supported by the International Sustainable Chemistry Collaborative Centre (ISC3).
One million (paper) satellites
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Published in print: 13 October 2023 Permissions Request permissions for this article.
The ecology of whales in a changing climate
Open in viewer The study of whale ecology did not begin until most populations had been depleted by commercial whaling. Some species still teeter on the edge of extinction, whereas others have shown encouraging signs of recovery. The Eastern Pacific population of gray whales (Eschrichtius robustus) was hunted to low levels in the 19th century but was protected from commercial harvest by the International Whaling Commission in 1947.
Probiotic-guided CAR-T cells for solid tumor targeting
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 16 August 2022 Accepted: 24 August 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments We thank M. Sadelain for providing the ffLuc+ Nalm6 acute lymphoblastic leukemia cell line, R. Schwabe for providing the Huh7 hepatoma cell line, and S. Acharyya for providing the PYMT-derived cell line. We thank N.
Early Homo erectus lived at high altitudes and produced both Oldowan and Acheulean tools
Research Article The Melka Kunture complex consists of a cluster of prehistoric sites that extends over tens of km2 in the Upper Awash, on the Ethiopian plateau at ≥2000 m above sea level (asl) (Fig. 1A). At this high altitude, the Pleistocene climate would have been cooler and wetter than at the lower elevations of the Rift Valley where most fossil evidence for early species of Homo derives.
A family portrait of human brain cells
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Published in print: 13 October 2023 Permissions Request permissions for this article. The authors thank J. R. Brown for help with editing the manuscript.
Groundhog Day
As a long-time academic and university administrator in the United States, I’ve attended more meetings than I can remember about what “counts” toward faculty hiring, promotion, tenure, and other rewards at institutions of higher education. These meetings always followed a similar pattern— and sadly, still do. A wise colleague referred to these meetings as “Groundhog Day,” after the movie about a single day that repeats over and over again.
Variant-adapted COVID-19 booster vaccines
Perspective Viewpoint: COVID-19 Current vaccines should be tailored to combat future SARS-CoV-2 variants Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines greatly reduced the burden of the COVID-19 pandemic and saved millions of lives (1). However, waning levels of circulating neutralizing antibodies and the continuous emergence of SARS-CoV-2 variants of concern decreased vaccine effectiveness and prompted the need for booster immunizations.
A quest into the human brain
Introduction to Special Issue Brain Cell Census Open in viewer Our brain is composed of 86 billion neurons and a similar number of non-neuronal cells.
A signaling lipid drives synapse formation
Brain function relies on the accurate formation of synaptic contacts, and alterations in this process are implicated in disease, including some psychiatric and neurodevelopmental disorders. Synapse formation requires the synthesis and transport of presynaptic proteins from the soma (which contains the nucleus) to the axon terminal. The identity and regulation of the transport organelle or organelles that are responsible for the assembly of presynaptic sites is not yet clear.
One million (paper) satellites
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Published in print: 13 October 2023 Permissions Request permissions for this article.
Freedom from free will
AAAS login provides access to Science for AAAS Members, and access to other journals in the Science family to users who have purchased individual subscriptions. Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
The legacy of Covid denial
References and Notes 1 J. Wallace, P. Goldsmith-Pinkham, J. L. Schwartz, “Excess death rates for Republicans and Democrats during the COVID-19 pandemic,” Working Paper 30512 (NBER, 2022) http://www.nber.org/papers/w30512. 2 D. Tahir, “The NIH halts a research project. Is it self-censorship?,” CBS News 5, August 2023 https://www.cbsnews.com/news/nih-halts-research-project-is-it-self-censorship/. Books 1 The Deadly Rise of Anti-science: A Scientist’s Warning Johns Hopkins University Press, 2023. 240 pp.
The complex dynamics of the 2023 Kahramanmaraş, Turkey, Mw 7.8-7.7 earthquake doublet
Supplementary Materials Materials and Methods Figs. S1 to S28 Tables S1 and S2 References and Notes 1 M. Edrik, M. B. D. Tümsa, A. Pınar, E. Altunel, A. C. Zülfikar, “A preliminary report on the February 6, 2023 earthquakes in Türkiye” (Temblor, 2023). 2 T. Lay, L. Ye, Y. Bai, K. F. Cheung, H. Kanamori, The 2018 MW 7.9 Gulf of Alaska earthquake: Multiple fault rupture in the Pacific plate. Geophys. Res. Lett.45, 9542–9551 (2018). 3 L. Meng, J.-P. Ampuero, J. Stock, Z. Duputel, Y. Luo, V. C.
AI safety on whose terms?
Rapid, widespread adoption of the latest large language models has sparked both excitement and concern about advanced artificial intelligence (AI). In response, many are looking to the field of AI safety for answers. Major AI companies are purportedly investing heavily in this young research program, even as they cut “trust and safety” teams addressing harms from current systems. Governments are taking notice too.
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