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Abstract Genetic inactivation of alpha-galactosidase A (GLA) causes Fabry disease, which is characterized by early cutaneous lesions such as angiokeratomas. However, the role of GLA in malignancies like melanoma remains poorly understood. Here, we show that high expression of GLA correlates with tumor development and progression, including in melanoma.
3. Experimental Design 3.1. Test Chamber Design A schematic diagram of the test chamber is illustrated in Figure 5. The tests were conducted in a laser-cut acrylic glass chamber with four cells, sitting on top of a solid-state heater/cooler, which controls the temperature of the cells. In the experiment, two test cells were used, where one was installed with a pair of the proposed soft layers inside and the other without to serve as the control group.
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