Identification of copy number variants and genome content differences In addition to this large region of genome variation on chromosome 6, we expected to identify numerous smaller copy-number variants (CNVs). As seen in the analysis of several well-annotated BACs, there are probes every ∼400 bp in low-copy genomic DNA (Figure 1). CNVs can be discovered by assessing the behavior of adjacent probes to identify segments of DNA that give consistently altered signal from two genomes.
