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Articles by Timothy Heisel
Assembly, stability, and dynamics of the infant gut microbiome are linked to bacterial strains and functions in mother's milk
Abstract The establishment of the gut microbiome in early life is critical for healthy infant development. Although human milk is recommended as the sole source of nutrition for the human infant, little is known about how variation in milk composition, and especially the milk microbiome, shapes the microbial communities in the infant gut.
Human Cytomegalovirus in breast milk is associated with milk composition, the infant gut microbiome, and infant growth
New Results doi: https://doi.org/10.1101/2023.07.19.549370 Abstract Human cytomegalovirus (CMV) is a highly prevalent herpesvirus that is often transmitted to the neonate via breast milk. Postnatal CMV transmission can have negative health consequences for preterm and immunocompromised infants, but any effects on healthy term infants are thought to be benign. Furthermore, the impact of CMV on the composition of the hundreds of bioactive factors in human milk has not been tested.
Human milk variation is shaped by maternal genetics and impacts the infant gut microbiome
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Human Milk Oligosaccharides Inhibit
Background: Human milk oligosaccharides (HMOs) are a highly abundant, diverse group of unique glycans that are postulated to promote the development of a protective bacterial microbiota in the intestine and prevent adhesive and invasive interactions of pathogenic bacteria with mucosal epithelia. Candida albicans, a prevalent fungal colonizer of the neonatal gut, causes the majority of fungal disease in premature infants and is highly associated with life-threatening intestinal disorders.
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