CONFLICT OF INTEREST STATEMENT Dr. Djousse reported receiving an investigator-initiated grant from Merck in the past. Dr. Djousse and Dr. Gaziano reported current research funding from Novartis. No other disclosures were reported. Supporting Information Filename Description jgs18700-sup-0001-supinfo.docxWord 2007 document , 486.9 KB Supplement Figure 1. CONSORT flow chart. Supplement Figure 2. Overall standardized differences before and after propensity score, and by frailty group. Supplement Table 1.