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Graphical Abstract Tissue Regeneration Inspired by the regulation of cellular circadian clock on tissue regeneration, in article number 2301037, Huitong Ruan, Wenguo Cui, Lianfu Deng, and co-workers report circadian-clock-regulating biomaterials that are fabricated using the air-microfluidic technique.
Abstract The localization of lesion cells and targeted regulation of organelle function can promote the lesion repair. However, conventional regulation is difficult to reach deep lesions and target mitochondria.
Abstract Although gradients play an essential role in guiding the function of tissues, achieving synchronous regeneration of gradient tissue injuries remains a challenge. Here, a gradient bimetallic (Cu and Zn) ion–based hydrogel was first constructed via the one-step coordinative crosslinking of sulfhydryl groups with copper and zinc ions for the microstructure reconstruction of the tendon-to-bone insertion.
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