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T’ng Choong

As seen in: Oxford Academic, TechTrends
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Articles by T’ng Choong

18 F-Fluorocholine uptake is greater by human supraclavicular brown than white adipose tissue and inversely associated with body mass index

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By T’ng Choong, von Kriegsheim, Giovanny Rodriguez
| TechTrends
Background Brown Adipose Tissue (BAT) is composed of mitochondrial-rich, multilocular adipocytes, which dissipate energy to produce heat. Quantification of BAT mass is most commonly performed by 18F-fluorodeoxyglucose positron emission tomography (PET), which requires antecedent cold exposure.
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UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors

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By T’ng Choong, Edinburgh Imaging Facility, van Beek, Edwin J. R
| Oxford Academic Verified
Brown adipose tissue (BAT) is a therapeutic target for obesity. 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET) is commonly used to quantify human BAT mass and activity. Detectable 18F-FDG uptake by BAT is associated with reduced prevalence of cardiometabolic disease. However, 18F-FDG uptake may not always be a reliable marker of BAT thermogenesis, for example insulin resistance may reduce glucose uptake. Uncoupling protein 1 (UCP1) is the key thermogenic protein in BAT.
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