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The ACE2 receptor accelerates but is not biochemically required for SARS-CoV-2 membrane fusion Marcos Cervantes, Tobin Hess, Giorgio Gianini Morbioli, Anjali Sengar and Peter Kasson Abstract The SARS-CoV-2 coronavirus infects human cells via the ACE2 receptor. Structural evidence suggests that ACE2 may not just serve as an attachment factor but also conformationally activate the SARS-CoV-2 spike protein for membrane fusion.
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