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Articles by Tomas Barta
Cumate-inducible models of MYC-driven neuroblastoma identify mitoribosomal synthetic lethality as a precision oncology vulnerability in MYC(N) -amplified tumors
Abstract Oncogenic MYC transcription factors profoundly rewire cellular programs, imposing therapeutically exploitable dependencies in MYC‑driven cancers such as high‑risk neuroblastoma. However, dissecting these synthetic lethal vulnerabilities using tunable gene expression remains challenging. Widely used tetracycline-regulated systems rely on inducers known to perturb mitochondrial function, introducing confounding off-target effects.
Long-term daily light exposure boosts human retinal organoid differentiation
Abstract Induced pluripotent stem cell-derived retinal organoids (ROs) have become promising personalized models to study inherited retinal diseases (IRDs) and develop new therapies. Although ROs mimic key retinal features and show some light responsiveness, their differentiation and maturation remain limited and lengthy.
Photostimulation improves maturation of human photoreceptors
Abstract The human retina contains photoreceptor cells that detect light and enable vision. The development of these cells involves a tightly regulated cascade of structural and molecular events, and their dysfunction leads to irreversible blindness in many retinal diseases. Human retinal organoids derived from stem cells have become powerful tools to model retinal development and disease, but they often remain immature and lack key features required for full function.
Stimulus duration encoding occurs early in the moth olfactory pathway - Communications Biology
Abstract Pheromones convey rich ethological information and guide insects’ search behavior. Insects navigating in turbulent environments are tasked with the challenge of coding the temporal structure of an odor plume, obliging recognition of the onset and offset of whiffs of odor. The coding mechanisms that shape odor offset recognition remain elusive.
Stimulus duration encoding occurs early in the moth olfactory pathway
Abstract Pheromones convey rich ethological information and guide insects' search behavior. Insects navigating in turbulent environments are tasked with the challenge of coding the temporal structure of an odor plume, obliging recognition of the onset and offset of whiffs of odor. The coding mechanisms that shape odor offset recognition remain elusive.
Shared input and recurrency in neural networks for metabolically efficient information transmission
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Barta T, Kostal L (2024) Shared input and recurrency in neural networks for metabolically efficient information transmission. PLoS Comput Biol 20(2): e1011896.
Illuminating the mechanism and allosteric behavior of NanoLuc luciferase - Nature Communications
Abstract NanoLuc, a superior β-barrel fold luciferase, was engineered 10 years ago but the nature of its catalysis remains puzzling. Here experimental and computational techniques are combined, revealing that imidazopyrazinone luciferins bind to an intra-barrel catalytic site but also to an allosteric site shaped on the enzyme surface. Structurally, binding to the allosteric site prevents simultaneous binding to the catalytic site, and vice versa, through concerted conformational changes.
MIR204 n.37C>T variant as a cause of chorioretinal dystrophy variably associated with iris coloboma, early‐onset cataracts and congenital glaucoma
Abstract Four members of a three-generation Czech family with early-onset chorioretinal dystrophy were shown to be heterozygous carriers of the n.37C>T in MIR204. The identification of this previously reported pathogenic variant confirms the existence of a distinct clinical entity caused by a sequence change in MIR204. Chorioretinal dystrophy was variably associated with iris coloboma, congenital glaucoma, and premature cataracts extending the phenotypic range of the condition.
Shared input and recurrency in neural networks for metabolically efficient information transmission
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The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling
Research ArticleBONE DISEASE The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling Fabiana Csukasi1, Ivan Duran1, Maya Barad1, Tomas Barta2, Iva Gudernova3, Lukas Trantirek4, Jorge H. Martin1, Caroline Y. Kuo5, Jeremy Woods5, Hane Lee6, Daniel H.
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