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Abstract What is known and objective Edoxaban has three dose adjustment factors (creatinine clearance, 15‐50 mL/min; body weight, 60 kg or less; and concomitant medication with potent P‐glycoprotein inhibitors) to prevent bleeding that results from elevated blood concentrations of the drug. A dose reduction (from 60 to 30 mg/day of edoxaban) is recommended for patients with even one of those.
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