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1 Introduction Primary liver cancer, originating from the liver, encompasses combined hepatocellular-cholangiocarcinoma (cHCC-CCA), cholangiocarcinoma (CCA), and hepatocellular carcinoma (HCC). HCC, 75%–85% of primary liver cancer, is predominantly driven by chronic liver diseases, including nonalcoholic fatty liver disease, alcoholic liver disease, and hepatitis B and C [1, 2].
Abstract In hepatocellular carcinoma (HCC), immunotherapy is vital for advanced-stage patients. However, diverse individual responses and tumor heterogeneity have resulted in heterogenous treatment outcomes. Our mechanistic investigations identified LAPTM4B as a crucial gene regulated by ETV1 (a transcription factor), especially in liver cancer stem cells (LCSCs). The influence of LAPTM4B on LCSCs is mediated via the Wnt1/c-Myc/β-catenin pathway.
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