This paper describes a substantial outbreak over a 3-year period. A coordinated area-based approach was a key feature of the outbreak, and substantial resources were applied to bring the outbreak under control. As yet, no definitive source was identified, nor reasons why a substantial number of herds were infected over a relatively short period. Past bTB history may have played a role, as bTB has been endemic in Ireland for many decades, including in north Co. Sligo during the years prior to 2014.