INTRODUCTION Knee OA is common in older individuals, affecting 263 million individuals worldwide.1 Individuals who have knee OA often display reductions in skeletal muscle mass, quality, and strength, yet the mechanisms behind these changes are broadly unknown.2, 3 Currently, physical activity appears to be the only therapy for muscle loss associated with knee OA, but its effectiveness declines with advanced age and is only moderately successful.4, 5 It is well appreciated that tissues...
