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Articles by Ulf Neumann
JCM | Free Full-Text | The Impact of Body Mass Composition on Outcome in Multiple Traumatized Patients-Results from the Fourth Thoracic and Third Lumbar Vertebrae: A Single-Center Retrospective Observational Study
Abstract : Background: Body mass composition (BC) was shown to correlate with outcome in patients after surgery and minor trauma. As BC is assessed using computed tomography (CT) and routinely applied in multiple trauma (MT), this study will help to analyze whether BC variables also correlate with outcome in trauma patients. Materials and Methods: Inclusion criteria were MT (Injury Severity Score (ISS) > 15) and whole-body CT (WBCT) scan on admission.
Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease
Abstract Neuronal network dysfunction is increasingly recognized as an early symptom in Alzheimer’s disease (AD) and may provide new entry points for diagnosis and intervention. Here, we show that amyloid-beta-induced hyperexcitability of hippocampal inhibitory parvalbumin (PV) interneurons importantly contributes to neuronal network dysfunction and memory impairment in APP/PS1 mice, a mouse model of increased amyloidosis.
Reply to: Does lymphovascular invasion really associate with decreased overall survival for patients with resected cholangiocarcinoma?
Georg Lurje x Search for articles by this author Correspondence Corresponding author. Clinical Lead Solid Organ Transplantation, Department of Surgery and Transplantation, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.. ∗,Correspondence information about the author Georg Lurje x Search for articles by this author Correspondence Corresponding author.
A microfluidics platform for combinatorial drug screening on cancer biopsies
Our platform (Fig. 1a) is based on a combination of plug technology26,27 with microfluidic Braille valves22,28 controlling individual fluid inlets of the microfluidic chip (Fig. 1a–d, Supplementary Fig. 1 and Supplementary Movie 1). To facilitate the alignment of the chip with the Braille display below, we designed additional channels that can be filled with dye (top and bottom left corner of the chip shown in Fig. 1a) and easily brought into line with particular Braille pins.
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