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Abstract Polyunsaturated fatty acids (PUFA) have been shown to reduce liver fat compared to saturated fat, but effects of a novel “anti-lipogenic” diet replacing carbohydrates with PUFA (LCPUFA) or a low-fat healthy Nordic diet (HND) rich in whole-grains are unknown.
References Moore JX. Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988–2012. Prev Chronic Dis; 14. Epub ahead of print 2017. https://doi.org/10.5888/pcd14.160287 World Health Organization [WHO]. Indicator Metadata Registry Details. https://www.who.int/https://www.who.int/ (2025, accessed 3 March 2025). Bouchard C. Genetics of obesity: what we have learned over decades of research. Obesity. 2021;29:802–20.
In the current issue of the Journal of Internal Medicine, Zhao et al. provided new evidence supporting the importance of diet quality in preventing premature deaths, as shown in a large US population of ∼371,000 men and women aged 50–71 years, followed for ∼23 years [6]. Carbohydrate and fat qualities are known to be a key determinant of health outcomes, but in this prospective study, it is shown in the context of both low and high carbohydrate intake.
1. Fat and fatty acid terminology, methods of analysis and fat digestion and metabolism: a background review paper. Ann Nutr Metab. 2009; 55: 8-43 2. Sioen I van Lieshout L Eilander A et al. Systematic review on n-3 and n-6 polyunsaturated fatty acid intake in European countries in light of the current recommendations—focus on specific population groups. Ann Nutr Metab. 2017; 70: 39-50 3.
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