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Aim: The biomedical application of contrast agents based on superparamagnetic iron oxide nanoparticles is still limited because of their short intravascular half-life. The potential of red blood cells (RBCs) loaded with new ferucarbotran nanoparticles as magnetic contrast agents with longer blood retention time has been investigated. Materials & methods: Ferucarbotran was loaded into RBCs by a procedure of hypotonic dialysis and isotonic resealing.
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