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Articles by Ulrike Hövelmann
Pharmacokinetic and pharmacodynamic properties of once‐weekly insulin icodec in individuals with type 1 diabetes
1 INTRODUCTION The need for multiple frequent insulin injections is considered a significant burden for individuals with type 1 diabetes (T1D) who receive insulin in a basal-bolus regimen.1 Approximately one third of people with T1D and approximately three quarters of their physicians reported regular omission of or nonadherence to daily basal insulin,2 which was shown to result in reduced glycaemic control3 and could cause diabetic ketoacidosis.4 Decreasing the frequency of basal insulin...
Pharmacokinetic and pharmacodynamic bioequivalence of biosimilar MYL‐1601D with US and European insulin aspart in healthy volunteers: A randomized, double‐blind, crossover, euglycaemic glucose clamp study
1 INTRODUCTION Insulin therapy is essential for the treatment of type 1 diabetes (T1D) and may be needed in type 2 diabetes (T2D). Currently available mealtime insulin analogues are effective, have a more physiological profile, and are associated with a lower risk of hypoglycaemia, but they are expensive.1 Insulin aspart is a rapid-acting insulin marketed as NovoLog (Ref-InsAsp-US) in the United States and NovoRapid (Ref-InsAsp-EU) in the European Union (EU).
Dasiglucagon-A Next-Generation Glucagon Analog for Rapid and Effective Treatment of Severe Hypoglycemia: Results of Phase 3 Randomized Double-Blind Clinical Trial | Diabetes Care
Emerging Therapies: Drugs and Regimens Abstract OBJECTIVE To evaluate the efficacy and safety of dasiglucagon, a ready-to-use, next-generation glucagon analog in aqueous formulation for subcutaneous dosing, for treatment of severe hypoglycemia in adults with type 1 diabetes.
Dasiglucagon: A Next-Generation Glucagon Analog for Rapid and Effective Treatment of Severe Hypoglycemia Results of Phase 3 Randomized Double-Blind Clinical Trial
Original Research Dasiglucagon: A Next-Generation Glucagon Analog for Rapid and Effective Treatment of Severe Hypoglycemia Results of Phase 3 Randomized Double-Blind Clinical Trial Thomas R. Pieber, Ronnie Aronson, Ulrike Hövelmann, Julie Willard, Leona Plum-Mörschel, Kim M.
Low doses of dasiglucagon consistently increase plasma glucose levels from hypoglycaemia and euglycaemia in people with type 1 diabetes mellitus
Currently available glucagon formulations have limited stability which hampers their use in dual‐hormone‐artificial pancreas‐systems. We characterized the pharmacokinetic and pharmacodynamic properties of dasiglucagon†, a novel, stable and liquid formulated glucagon‐analogue, during hypoglycaemic and euglycaemic conditions in adult patients with type‐1 diabetes mellitus.
Pharmacokinetic and Pharmacodynamic Characteristics of Dasiglucagon, a Novel Soluble and Stable Glucagon Analog
Pharmacokinetic and Pharmacodynamic Characteristics of Dasiglucagon, a Novel Soluble and Stable Glucagon Analog Ulrike Hövelmann, Britta Væver Bysted, Ulrik Mouritzen, Francesca Macchi, Daniela Lamers, Birgit Kronshage, Daniél Vega Møller, Tim Heise Diabetes Care Mar 2018, 41 (3) 531-537; DOI: 10.2337/dc17-1402
Insulin Injection Into Lipohypertrophic Tissue: Blunted and More Variable Insulin Absorption and Action and Impaired Postprandial Glucose Control
Insulin Injection Into Lipohypertrophic Tissue: Blunted and More Variable Insulin Absorption and Action and Impaired Postprandial Glucose Control Susanne Famulla, Ulrike Hövelmann, Annelie Fischer, Hans-Veit Coester, Lidia Hermanski, Matthias Kaltheuner, Lars Kaltheuner, Lutz Heinemann, Tim Heise, Laurence Hirsch Diabetes Care Sep 2016, 39 (9) 1486-1492; DOI: 10.2337/dc16-0610
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