After removing duplicates, a total of 407 studies were identified by the literature search and independently screened. Of these articles, 52 fit the inclusion criteria and were further assessed for eligibility (Fig. 1Fig. 1): 17 comparative studies [6x[6]Gelbard, M., Goldstein, I., Hellstrom, W.J.G. et al. Clinical efficacy, safety and tolerability of collagenase Clostridium histolyticum for the treatment of Peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies.
